The Presbyterian Church (U.S.A.) is the second largest denominational investor in Oikocredit. The Presbyterian Foundation, Presbyterian Women, Self-Development of People, and the Presbyterian Hunger Program hold investments totaling over two million dollars.

Many PC(USA) congregations have also invested as part of their commitment to just and sustainable development. These investments range from $1,000 to the $500,000 in Oikocredit shares owned by East Liberty Presbyterian Church in Pittsburgh, Pennsylvania.

Many Presbyterian individuals and organizations invest as well.